Werthmann et al. 2018 [166]
A 68-year-old female patient with pulmonary and osseous metastasized rectal cancer who has been pre-treated with intensive radiotherapy and chemotherapy received intralesional mistletoe applications into a large, painful skull bone metastasis. The pain disappeared, the lesion softened and decreased by more than half within an eight-month lasting continuous mistletoe therapy. Her condition remained stable for two years.